Malarial infection characterised by paroxysms (stages of chills, fever, and sweating at regularly recurring times) and followed by an interval or intermission of varying duration. Popularly, the disease was known as “fever and ague”, “chill fever”, “the shakes.” An intermittent fever, with cold fits succeeded by hot. Ague fit: the paroxysm of the ague. See also malaria. Ague cake is a hardening of the spleen caused by malaria.